Journal: iScience
Article Title: Benzotriazole derivatives as alternate O- acetylserine sulfhydrylase substrates to impair cysteine biosynthesis in gram-negative bacteria
doi: 10.1016/j.isci.2025.113818
Figure Lengend Snippet: Fractional inhibitory concentration (FIC) index of the best combinations among 3d , 3l , and 3n BT derivatives with different antibiotics Antibiotic-BT derivatives were tested on E. coli ATCC 25922 (magenta), S. Typhimurium ATCC 14028 (violet), and K. pneumoniae ATCC 13883 (light blue). The data represent the FIC index between colistin, gentamicin, ciprofloxacin, or ampicillin and the most effective concentration of BT derivative. An FIC index ≤0.5 is indicative of synergy of action, 0.5 < FIC ≤1 shows additivity of action, and 1 < FIC <4 shows indifference between the couples of considered compounds. The complete set of data is reported in .
Article Snippet: Growth curves and intracellular thiol analysis E. coli ATCC 25922 growth curves and intracellular thiol analysis in the presence of compounds 3d (red), 3l (dark yellow), and 3n (green) at the static MICs (A and B) and at 3-fold static MICs (C and D).
Techniques: Concentration Assay